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HIV-Protease Inhibitory & Antidiabetic Activities of Natural Products

3,43700 руб.

Рубрика: Генетика. Микробиология

Автор(ы): Anuya Rege,Ramkrishna Ambaye and Abhay Chowdhary

Язык: Английский

Издательство: LAP Lambert Academic Publishing

ISBN: 9783659541582

Баркод: 9783659541582

Год: 2014

Наличие книги: Отгружается в течение двух недель

Дополнительные характеристики

Страниц: 100

Описание книги

Ethanolic & aqueous extracts of Ocimum sanctum, Tinospora cordifolia, Withania somnifera, Avicennia officinalis, Rhizophora mucronata & Shilajit were included in the present in vitro study. Pepsin was used as a substitute for HIV-protease to evaluate effect of these extracts, as pepsin has great structural and functional similarities with HIV-protease. Pepsin assay could be used for preliminary screening of natural products for probable HIV-protease inhibitory activity. The use of combination antiretroviral therapy has yielded clinical benefits for HIV-infected patients, however, it has also led to adverse metabolic effects such as diabetes & when HIV & diabetes intersect, the treatment regimens required for both diseases can be overwhelming for patients. Hence, these extracts were further evaluated for their antidiabetic effect using alpha-Amylase & alpha-Glucosidase enzymes. O. sanctum, T. cordifolia, R. mucronata & Shilajit exhibited putative HIV-protease inhibitory activitiy....

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