Медицинская литература


Proteins from Archaea

8,03600 руб.

Рубрика: Генетика. Микробиология

Автор(ы): Torsten Thomas

Язык: Английский

Издательство: LAP Lambert Academic Publishing

ISBN: 9783838334042

Баркод: 9783838334042

Год: 2009

Наличие книги: Отгружается в течение двух недель

Дополнительные характеристики

Страниц: 240

Описание книги

Despite the abundance of Archaea in cold environments little attention has been given to their adaptive response to low temperature. The aim of this book was to investigate protein in adaptation in the psychrotolerant archaeon Methanococcoides burtonii by comparative analysis with the mesophile Methanococcoides methylutens and the thermophile Methanosarcina thermophila. Elongation factor was chosen as a model protein for this study. Structural analysis by homology modeling revealed a number of features that may confer flexibility or thermolability to the M. burtonii EF-2 and that may be important for low-temperature activity. These included the loss of salt-bridges, the loss of proline residues in loop structures and the decreased packaging density in hydrophobic core regions. These studies demonstrated the activity and the stability of EF-2 is adapted for the growth of M. burtonii in its natural environment. The adaptive processes include the modification of EF-2 protein structure,...

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