Медицинская литература


Molecular characterization of ESBL producing Klebsiella SPP isolates

8,03600 руб.

Рубрика: Генетика. Микробиология

Автор(ы): Sobhan Ghafourian,Sekawi. Z and Sadeghifard. N

Язык: Английский

Издательство: LAP Lambert Academic Publishing

ISBN: 9783844317312

Баркод: 9783844317312

Год: 2011

Наличие книги: Отгружается в течение двух недель

Дополнительные характеристики

Страниц: 224

Описание книги

ESBLs are known as extended-spectrum because they are able to hydrolyze a broader spectrum of beta- lactam antibiotics than the simple parent beta- lactamases from which they are derived. Such ESBLs have also the ability to inactivate beta-lactam antibiotics containing an oxyimino-group such as oxyimino-cephalosporins (eg; ceftazidime, ceftriaxone, cefotaxime) as well as oxyimino- monobactam. Furthermore, they are not active against cephamycins and carbapenems. Generally, they are inhibited by beta-lactamase-inhibitors such as clavulanate and tazobactam. ESBLs have been found in a wide range of Gram-negative rods. However, the vast majority of strains expressing these enzymes belong to the Enterobacteriaceae family. K.pneumoniae remains as the major ESBL-producer.

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